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Combining selinexor with dexamethasone is effective for patients with treatment-resistant multiple myeloma, according to a study published in The New England Journal of Medicine. Proteins and messenger RNAs play an important part of cancer cell growth, and selinexor has an unprecedented mechanism...
Researchers have linked inherited mutations in the BRCA2 gene with an increased risk of developing non-Hodgkin lymphoma in children and adolescents, according to a study published in JAMA Oncology. “The BRCA family of genes are known to be linked to risk for breast and ovarian cancer as well as...
Individuals with low- or intermediate-risk monoclonal gammopathy of undetermined significance (MGUS) can convert to high-risk MGUS and progress to multiple myeloma within a 5-year window, according to a study published in JAMA Oncology. The findings support recommendations for annual blood tests...
A 2-dose course of recombinant zoster vaccine reduced the incidence of herpes zoster in autologous hematopoietic stem cell transplant (HSCT) recipients, according to a study published in JAMA. “This trial is important because it demonstrates that the vaccine works in severely immunosuppressed...
The US Food and Drug Administration (FDA) has approved selinexor (Xpovio) in combination with dexamethasone for adult patients with relapsed or refractory multiple myeloma (MM) who have received at least 4 prior therapies and whose disease is refractory to at least 2 proteasome inhibitors, at least...

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